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Increase in TGF-β Secreting CD4(+)CD25(+) FOXP3(+) T Regulatory Cells in Anergic Lepromatous Leprosy Patients

BACKGROUND: Lepromatous leprosy caused by Mycobacterium leprae is associated with antigen specific T cell unresponsiveness/anergy whose underlying mechanisms are not fully defined. We investigated the role of CD25(+)FOXP3(+) regulatory T cells in both skin lesions and M.leprae stimulated PBMC cultur...

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Hlavní autoři: Saini, Chaman, Ramesh, Venkatesh, Nath, Indira
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894184/
https://ncbi.nlm.nih.gov/pubmed/24454972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002639
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