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Leprosy Reactions Show Increased Th17 Cell Activity and Reduced FOXP3+ Tregs with Concomitant Decrease in TGF-β and Increase in IL-6

BACKGROUND: 50% of leprosy patients suffer from episodes of Type 1/ reversal reactions (RR) and Type 2/ Erythema Nodosum Leprosum (ENL) reactions which lead to morbidity and nerve damage. CD4(+) subsets of Th17 cells and CD25(+)FOXP3(+) regulatory T cells (Tregs) have been shown to play a major role...

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Dettagli Bibliografici
Pubblicato in:PLoS Negl Trop Dis
Autori principali: Saini, Chaman, Siddiqui, Anisuddin, Ramesh, Venkatesh, Nath, Indira
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818038/
https://ncbi.nlm.nih.gov/pubmed/27035913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004592
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