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Leprosy Reactions Show Increased Th17 Cell Activity and Reduced FOXP3+ Tregs with Concomitant Decrease in TGF-β and Increase in IL-6
BACKGROUND: 50% of leprosy patients suffer from episodes of Type 1/ reversal reactions (RR) and Type 2/ Erythema Nodosum Leprosum (ENL) reactions which lead to morbidity and nerve damage. CD4(+) subsets of Th17 cells and CD25(+)FOXP3(+) regulatory T cells (Tregs) have been shown to play a major role...
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| Publicado no: | PLoS Negl Trop Dis |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4818038/ https://ncbi.nlm.nih.gov/pubmed/27035913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004592 |
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