Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α′ subunits reduces orthotopic xenograft prostate tumors in mice

CK2 is a highly conserved, ubiquitous, signal responsive protein serine/threonine kinase. CK2 promotes cell proliferation and suppresses apoptosis, and increased CK2 expression is observed in all cancers examined. We previously reported that direct injection of antisense (AS) CK2α phosphorothioate o...

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Detalhes bibliográficos
Main Authors: Trembley, Janeen H., Unger, Gretchen M., Tobolt, Diane K., Korman, Vicci L., Wang, Guixia, Ahmad, Kashif A., Slaton, Joel W., Kren, Betsy T., Ahmed, Khalil
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893918/
https://ncbi.nlm.nih.gov/pubmed/21761204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-011-0943-x
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