Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain

BACKGROUND: Intracytoplasmic inclusions composed of filamentous tau proteins are defining characteristics of neurodegenerative tauopathies, but it remains unclear why different tau isoforms accumulate in different diseases and how they induce abnormal filamentous structures and pathologies. Two tau...

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Detalhes bibliográficos
Main Authors: Dan, Ayaho, Takahashi, Muneaki, Masuda-Suzukake, Masami, Kametani, Fuyuki, Nonaka, Takashi, Kondo, Hiromi, Akiyama, Haruhiko, Arai, Takao, Mann, David MA, Saito, Yuko, Hatsuta, Hiroyuki, Murayama, Shigeo, Hasegawa, Masato
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893535/
https://ncbi.nlm.nih.gov/pubmed/24252707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-54
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