Prophylactic and therapeutic testing of Nicotiana-derived RSV-neutralizing human monoclonal antibodies in the cotton rat model

Severe lower respiratory tract infection in infants and small children is commonly caused by respiratory syncytial virus (RSV). Palivizumab (Synagis(®)), a humanized IgG(1) monoclonal antibody (mAb) approved for RSV immunoprophylaxis in at-risk neonates, is highly effective, but pharmacoeconomic ana...

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Main Authors: Zeitlin, Larry, Bohorov, Ognian, Bohorova, Natasha, Hiatt, Andrew, Kim, Do H., Pauly, Michael H., Velasco, Jesus, Whaley, Kevin J., Barnard, Dale L., Bates, John T., Crowe, James E., Piedra, Pedro A., Gilbert, Brian E.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893236/
https://ncbi.nlm.nih.gov/pubmed/23396091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.23281
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