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Imaging Pharmacodynamics of the alpha Folate Targeted Thymidylate Synthase Inhibitor BGC 945
The assessment of tissue-specific pharmacodynamics is desirable in the development of tumour-targeted therapies. Plasma deoxyuridine (dUrd) levels - a measure of systemic thymidylate synthase (TS) inhibition - has limited application for studying the pharmacodynamics of novel TS inhibitors targeted...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3892028/ https://ncbi.nlm.nih.gov/pubmed/18483267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0135 |
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