Imaging Pharmacodynamics of the alpha Folate Targeted Thymidylate Synthase Inhibitor BGC 945

The assessment of tissue-specific pharmacodynamics is desirable in the development of tumour-targeted therapies. Plasma deoxyuridine (dUrd) levels - a measure of systemic thymidylate synthase (TS) inhibition - has limited application for studying the pharmacodynamics of novel TS inhibitors targeted...

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Autori principali: Pillai, Radhakrishna G., Forster, Martin, Perumal, Meg, Mitchell, Fraser, Leyton, Julius, Aibgirhio, Franklin I., Golovko, Oksana, Jackman, Ann L., Aboagye, Eric O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892028/
https://ncbi.nlm.nih.gov/pubmed/18483267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0135
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