Synthesis and molecular modeling of six novel monastrol analogues: evaluation of cytotoxicity and kinesin inhibitory activity against HeLa cell line

BACKGROUND AND THE PURPOSE OF THE STUDY: A common approach in cancer chemotherapy is development of drugs that interrupt the mitosis phase of cell division. Dimethylenastron is a known kinesin inhibitor. In this study, six novel dimethylenastron analogues (4a-f), in which 3-hydroxyphenyl substituent...

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Hauptverfasser: Abnous, Khalil, Barati, Batoul, Mehri, Soghra, Masboghi Farimani, Mohammad Reza, Alibolandi, Mona, Mohammadpour, Fatemeh, Ghandadi, Morteza, Hadizadeh, Farzin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891991/
https://ncbi.nlm.nih.gov/pubmed/24355209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2008-2231-21-70
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