Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair

Inhibition of DNA repair is a recognized mechanism for arsenic enhancement of ultraviolet radiation-induced DNA damage and carcinogenesis. Poly(ADP-ribose) polymerase-1 (PARP-1), a zinc finger DNA repair protein, has been identified as a sensitive molecular target for arsenic. The zinc finger domain...

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Detaylı Bibliyografya
Asıl Yazarlar: Sun, Xi, Zhou, Xixi, Du, Libo, Liu, Wenlan, Liu, Yang, Hudson, Laurie G., Liu, Ke Jian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891920/
https://ncbi.nlm.nih.gov/pubmed/24275069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.11.010
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