Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR

Most cystic fibrosis is caused by a deletion of a single residue (F508) in CFTR that disrupts the folding and biosynthetic maturation of the ion channel protein. Progress towards understanding the underlying mechanisms and overcoming the defect remain incomplete. Here we show that the thermal instab...

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Detaylı Bibliyografya
Asıl Yazarlar: Aleksandrov, Andrei A., Kota, Pradeep, Cui, Liying, Jensen, Tim, Alekseev, Alexey E., Reyes, Santiago, He, Lihua, Gentzsch, Martina, Aleksandrov, Luba A., Dokholyan, Nikolay V., Riordan, John R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891843/
https://ncbi.nlm.nih.gov/pubmed/22406676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.03.001
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