Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR

Most cystic fibrosis is caused by a deletion of a single residue (F508) in CFTR that disrupts the folding and biosynthetic maturation of the ion channel protein. Progress towards understanding the underlying mechanisms and overcoming the defect remain incomplete. Here we show that the thermal instab...

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Autors principals: Aleksandrov, Andrei A., Kota, Pradeep, Cui, Liying, Jensen, Tim, Alekseev, Alexey E., Reyes, Santiago, He, Lihua, Gentzsch, Martina, Aleksandrov, Luba A., Dokholyan, Nikolay V., Riordan, John R.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891843/
https://ncbi.nlm.nih.gov/pubmed/22406676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.03.001
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