Discrete effects of A57G-myosin essential light chain mutation associated with familial hypertrophic cardiomyopathy

The functional consequences of the familial hypertrophic cardiomyopathy A57G (alanine-to-glycine) mutation in the myosin ventricular essential light chain (ELC) were assessed in vitro and in vivo using previously generated transgenic (Tg) mice expressing A57G-ELC mutant vs. wild-type (WT) of human c...

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Autors principals: Kazmierczak, Katarzyna, Paulino, Ellena C., Huang, Wenrui, Muthu, Priya, Liang, Jingsheng, Yuan, Chen-Ching, Rojas, Ana I., Hare, Joshua M., Szczesna-Cordary, Danuta
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2013
Matèries:
Integrative Cardiovascular Physiology and Pathophysiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891242/
https://ncbi.nlm.nih.gov/pubmed/23748425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00107.2013
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