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Optical control of trimeric P2X receptors and acid-sensing ion channels

P2X receptors are trimeric membrane proteins that function as ion channels gated by extracellular ATP. We have engineered a P2X2 receptor that opens within milliseconds by irradiation at 440 nm, and rapidly closes at 360 nm. This requires bridging receptor subunits via covalent attachment of 4,4...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Browne, Liam E., Nunes, João P. M., Sim, Joan A., Chudasama, Vijay, Bragg, Laricia, Caddick, Stephen, Alan North, R.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890850/
https://ncbi.nlm.nih.gov/pubmed/24367083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318582111
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