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Activation of Trimeric P2X2 Receptors by Fewer than Three ATP Molecules

P2X receptors are trimeric membrane proteins. When they bind extracellular ATP, a conformational change occurs that opens a transmembrane ion channel. The ATP-binding pocket is formed in a cleft between two subunits, and a critical amino acid residue for ATP contact is Lys(69) (P2X2 numbering). In t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Stelmashenko, Olga, Lalo, Ulyana, Yang, Yue, Bragg, Laricia, North, R. Alan, Compan, Vincent
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463222/
https://ncbi.nlm.nih.gov/pubmed/22828800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.080903
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