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Optical control of trimeric P2X receptors and acid-sensing ion channels
P2X receptors are trimeric membrane proteins that function as ion channels gated by extracellular ATP. We have engineered a P2X2 receptor that opens within milliseconds by irradiation at 440 nm, and rapidly closes at 360 nm. This requires bridging receptor subunits via covalent attachment of 4,4...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3890850/ https://ncbi.nlm.nih.gov/pubmed/24367083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318582111 |
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