Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis

The B-cell CLL/lymphoma 2 (Bcl2) relative Myeloid cell leukemia sequence 1 (Mcl1) is essential for cell survival during development and for tissue homeostasis throughout life. Unlike Bcl2, Mcl1 turns over rapidly, but the physiological significance of its turnover has been unclear. We have gained in...

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Main Authors: Okamoto, Toru, Coultas, Leigh, Metcalf, Donald, van Delft, Mark F., Glaser, Stefan P., Takiguchi, Megumi, Strasser, Andreas, Bouillet, Philippe, Adams, Jerry M., Huang, David C. S.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890801/
https://ncbi.nlm.nih.gov/pubmed/24363325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321259110
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