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Direct observation of a transient ternary complex during IκBα-mediated dissociation of NF-κB from DNA

We previously demonstrated that IκBα markedly increases the dissociation rate of DNA from NF-κB. The mechanism of this process remained a puzzle because no ternary complex was observed, and structures show that the DNA and IκBα binding sites on NF-κB are overlapping. The kinetics of interaction of I...

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Bibliografski detalji
Glavni autori: Alverdi, Vera, Hetrick, Byron, Joseph, Simpson, Komives, Elizabeth A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890772/
https://ncbi.nlm.nih.gov/pubmed/24367071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318115111
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