XPC promotes MDM2-mediated degradation of the p53 tumor suppressor

Although ubiquitin receptor Rad23 has been implicated in bringing ubiquitylated p53 to the proteasome, how Rad23 recognizes p53 remains unclear. We demonstrate that XPC, a Rad23-binding protein, regulates p53 turnover. p53 protein in XPC-deficient cells remains ubiquitylated, but its association wit...

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Main Authors: Krzeszinski, Jing Yan, Choe, Vitnary, Shao, Jia, Bao, Xin, Cheng, Haili, Luo, Shiwen, Huo, Keke, Rao, Hai
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2014
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890342/
https://ncbi.nlm.nih.gov/pubmed/24258024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-05-0293
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