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XPC promotes MDM2-mediated degradation of the p53 tumor suppressor
Although ubiquitin receptor Rad23 has been implicated in bringing ubiquitylated p53 to the proteasome, how Rad23 recognizes p53 remains unclear. We demonstrate that XPC, a Rad23-binding protein, regulates p53 turnover. p53 protein in XPC-deficient cells remains ubiquitylated, but its association wit...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Cell Biology
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3890342/ https://ncbi.nlm.nih.gov/pubmed/24258024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-05-0293 |
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