Eicosapentaenoic Acid Activates RAS/ERK/C/EBPβ Pathway through H-Ras Intron 1 CpG Island Demethylation in U937 Leukemia Cells

Epigenetic alterations, including aberrant DNA methylation, contribute to tumor development and progression. Silencing of tumor suppressor genes may be ascribed to promoter DNA hypermethylation, a reversible phenomenon intensely investigated as potential therapeutic target. Previously, we demonstrat...

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Bibliografische gegevens
Hoofdauteurs: Ceccarelli, Veronica, Nocentini, Giuseppe, Billi, Monia, Racanicchi, Serena, Riccardi, Carlo, Roberti, Rita, Grignani, Francesco, Binaglia, Luciano, Vecchini, Alba
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890293/
https://ncbi.nlm.nih.gov/pubmed/24454781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085025
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