Eicosapentaenoic Acid Activates RAS/ERK/C/EBPβ Pathway through H-Ras Intron 1 CpG Island Demethylation in U937 Leukemia Cells

Epigenetic alterations, including aberrant DNA methylation, contribute to tumor development and progression. Silencing of tumor suppressor genes may be ascribed to promoter DNA hypermethylation, a reversible phenomenon intensely investigated as potential therapeutic target. Previously, we demonstrat...

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Detalhes bibliográficos
Main Authors: Ceccarelli, Veronica, Nocentini, Giuseppe, Billi, Monia, Racanicchi, Serena, Riccardi, Carlo, Roberti, Rita, Grignani, Francesco, Binaglia, Luciano, Vecchini, Alba
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890293/
https://ncbi.nlm.nih.gov/pubmed/24454781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085025
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