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Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells
The AML1/ETO and PML/RARα leukemia fusion proteins induce acute myeloid leukemia by acting as transcriptional repressors. They interact with corepressors, such as N-CoR and SMRT, that recruit a multiprotein complex containing histone deacetylases on crucial myeloid differentiation genes. This leads...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC556397/ https://ncbi.nlm.nih.gov/pubmed/15729358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600593 |
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