Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice

The chronic and systemic administration of rapamycin extends life span in mammals. Rapamycin is a pharmacological inhibitor of mTOR. Metformin also inhibits mTOR signaling but by activating the upstream kinase AMPK. Here we report the effects of chronic and systemic administration of the two mTOR in...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Kusne, Yael, Goldberg, Emily L., Parker, Sara S., Hapak, Sophie M., Maskaykina, Irina Y., Chew, Wade M., Limesand, Kirsten H., Brooks, Heddwen L., Price, Theodore J., Sanai, Nader, Nikolich-Zugich, Janko, Ghosh, Sourav
Format: Artigo
Jezik:Inglês
Izdano: Springer Netherlands 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889877/
https://ncbi.nlm.nih.gov/pubmed/23949159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-013-9572-5
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki