A novel human high-risk ependymoma stem cell model reveals the differentiation inducing potential of the histone deacetylase inhibitor Vorinostat

Incompletely resectable ependymomas are associated with a poor prognosis despite intensive radio- and chemotherapy. Novel treatments have been difficult to develop due to the lack of appropriate models. Here, we report on the generation of a high risk cytogenetic group 3 and molecular group C ependy...

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Hoofdauteurs: Milde, Till, Kleber, Susanne, Korshunov, Andrey, Witt, Hendrik, Hielscher, Thomas, Koch, Philipp, Kopp, Hans-Georg, Jugold, Manfred, Deubzer, Hedwig E., Oehme, Ina, Lodrini, Marco, Gröne, Hermann-Josef, Benner, Axel, Brüstle, Oliver, Gilbertson, Richard J., von Deimling, Andreas, Kulozik, Andreas E., Pfister, Stefan M., Martin-Villalba, Ana, Witt, Olaf
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889656/
https://ncbi.nlm.nih.gov/pubmed/21863243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-011-0866-3
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