Pharmacokinetics of dolutegravir in HIV-seronegative subjects with severe renal impairment

PURPOSE: Dolutegravir (DTG), an unboosted HIV integrase inhibitor (INI), is metabolized by UGT1A1 and to a minor extent by CYP3A. Renal elimination of unchanged DTG is very low (< 1 %). As renal impairment may affect pharmacokinetics (PK), even for drugs primarily metabolized or secreted in bile,...

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Autors principals: Weller, Stephen, Borland, Julie, Chen, Shuguang, Johnson, Mark, Savina, Paul, Wynne, Brian, Wajima, Toshihiro, Peppercorn, Amanda F., Piscitelli, Stephen C.
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2013
Matèries:
Clinical Trial
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889630/
https://ncbi.nlm.nih.gov/pubmed/24096683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-013-1590-9
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