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A Mutation in the N Domain of Escherichia coli Lon Stabilizes Dodecamers and Selectively Alters Degradation of Model Substrates

Escherichia coli Lon, an ATP-dependent AAA(+) protease, recognizes and degrades many different substrates, including the RcsA and SulA regulatory proteins. More than a decade ago, the E240K mutation in the N domain of Lon was shown to prevent degradation of RcsA but not SulA in vivo. Here, we charac...

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Detalhes bibliográficos
Main Authors: Wohlever, Matthew L., Baker, Tania A., Sauer, Robert T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889616/
https://ncbi.nlm.nih.gov/pubmed/24123818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00886-13
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