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The Rho Guanine Nucleotide Exchange Factor Syx Regulates the Balance of Dia and ROCK Activities To Promote Polarized-Cancer-Cell Migration

The role of RhoA in promoting directed cell migration has been complicated by studies showing that it is activated both in the front and the rear of migrating cells. We report here that the RhoA-specific guanine nucleotide exchange factor Syx is required for the polarity of actively migrating brain...

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Detalhes bibliográficos
Main Authors: Dachsel, Justus C., Ngok, Siu P., Lewis-Tuffin, Laura J., Kourtidis, Antonis, Geyer, Rory, Johnston, Lauren, Feathers, Ryan, Anastasiadis, Panos Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889543/
https://ncbi.nlm.nih.gov/pubmed/24126053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00565-13
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