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Use of Different Parameters and Equations for Calculation of IC(50) Values in Efflux Assays: Potential Sources of Variability in IC(50) Determination

Drug interactions due to efflux transporters may result in one drug increasing or decreasing the systemic exposure of a second drug. The potential for in vivo drug interactions is estimated through in vitro cell assays. Variability in in vitro parameter determination (e.g., IC(50) values) among labo...

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Detalhes bibliográficos
Main Authors: Volpe, Donna A., Hamed, Salaheldin S., Zhang, Lei K.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889528/
https://ncbi.nlm.nih.gov/pubmed/24338112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-013-9554-7
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