NMR-Based Activity Assays for Determining Compound Inhibition, IC(50) Values, Artifactual Activity, and Whole-Cell Activity of Nucleoside Ribohydrolases

NMR spectroscopy is often used for the identification and characterization of enzyme inhibitors in drug discovery, particularly in the context of fragment screening. NMR-based activity assays are ideally suited to work at the higher concentrations of test compounds required to detect these weaker in...

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Foilsithe in:J Vis Exp
Main Authors: Stockman, Brian J., Kaur, Abinash, Persaud, Julia K., Mahmood, Maham, Thuilot, Samantha F., Emilcar, Melissa B., Canestrari, Madison, Gonzalez, Juliana A., Auletta, Shannon, Sapojnikov, Vital, Caravan, Wagma, Muellers, Samantha N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061360/
https://ncbi.nlm.nih.gov/pubmed/31305530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/59928
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