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CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation

The P2X7 receptor is a trimeric ATP-gated cation channel important in health and disease. We have observed that the specific phospholipase D (PLD)1 antagonist, CAY10593 impairs P2X7-induced shedding of the ‘low affinity’ IgE receptor, CD23. The current study investigated the mode of action of this c...

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Detalhes bibliográficos
Main Authors: Pupovac, A., Stokes, L., Sluyter, R.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889394/
https://ncbi.nlm.nih.gov/pubmed/23793974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-013-9371-6
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