Highlight article: Ligand-independent activation of the P2X7 receptor by Hsp90 inhibition stimulates motor neuron apoptosis

Activation of the extracellular ATP ionotropic receptor P2X7 stimulates motor neuron apoptosis, whereas its inhibition in cell and animal models of amyotrophic lateral sclerosis can be protective. These observations suggest that P2X7 receptor activation is relevant to motor neuron disease and that i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Exp Biol Med (Maywood)
Prif Awduron: Strayer, Amy L, Dennys-Rivers, Cassandra N, Ricart, Karina C, Bae, Narae, Beckman, Joseph S, Franco, Maria Clara, Estevez, Alvaro G
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: SAGE Publications 2019
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690143/
https://ncbi.nlm.nih.gov/pubmed/31142143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370219853798
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