Highlight article: Ligand-independent activation of the P2X7 receptor by Hsp90 inhibition stimulates motor neuron apoptosis

Activation of the extracellular ATP ionotropic receptor P2X7 stimulates motor neuron apoptosis, whereas its inhibition in cell and animal models of amyotrophic lateral sclerosis can be protective. These observations suggest that P2X7 receptor activation is relevant to motor neuron disease and that i...

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發表在:Exp Biol Med (Maywood)
Main Authors: Strayer, Amy L, Dennys-Rivers, Cassandra N, Ricart, Karina C, Bae, Narae, Beckman, Joseph S, Franco, Maria Clara, Estevez, Alvaro G
格式: Artigo
語言:Inglês
出版: SAGE Publications 2019
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690143/
https://ncbi.nlm.nih.gov/pubmed/31142143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370219853798
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