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Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors
ATP-gated purinergic P2X4 receptors (P2X4Rs) are the most alcohol-sensitive P2XR subtype. We recently reported that ivermectin (IVM), an antiparasitic used in animals and humans, antagonized ethanol inhibition of P2X4Rs. Furthermore, IVM reduced ethanol intake in mice. The first molecular model of t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Netherlands
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3889384/ https://ncbi.nlm.nih.gov/pubmed/23817978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-013-9373-4 |
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