Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity

Mouse models of alcohol use disorder (AUD) revealed purinergic P2X4 receptors (P2X4Rs) as a promising target for AUD drug development. We have previously demonstrated that residues at the transmembrane (TM)–ectodomain interface and within the TM1 segment contribute to the formation of an ethanol act...

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Detalhes bibliográficos
Main Authors: Maya Popova, Larry Rodriguez, James R. Trudell, Sylvia Nguyen, Michael Bloomfield, Daryl L. Davies, Liana Asatryan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-04-01
Colecção:International Journal of Molecular Sciences
Assuntos:
purinergic (P2X4) receptor
TM1 and TM2 segments
ethanol and agonist action
mutagenesis
molecular model
Acesso em linha:https://www.mdpi.com/1422-0067/21/7/2471
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