Chargement en cours...
The iSH2 domain of PI 3-kinase is a Rigid Tether for p110 and Not a Conformational Switch
Class I PI 3-kinases are heterodimeric proteins with distinct catalytic (p110) and regulatory (p85) subunits. The minimal fragment of p85 capable of regulating p110 activity (p85ni) is the N-terminal SH2 domain linked to the iSH2 coiled-coil domain. We used cysteine mutagenesis and (14)C-NEM labelin...
Enregistré dans:
| Auteurs principaux: | , , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2004
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3889214/ https://ncbi.nlm.nih.gov/pubmed/15542063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2004.09.032 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|