The iSH2 domain of PI 3-kinase is a Rigid Tether for p110 and Not a Conformational Switch

Class I PI 3-kinases are heterodimeric proteins with distinct catalytic (p110) and regulatory (p85) subunits. The minimal fragment of p85 capable of regulating p110 activity (p85ni) is the N-terminal SH2 domain linked to the iSH2 coiled-coil domain. We used cysteine mutagenesis and (14)C-NEM labelin...

詳細記述

保存先:
書誌詳細
主要な著者: Fu, Zheng, Aronoff-Spencer, Eliah, Wu, Haiyan, Gerfen, Gary J., Backer, Jonathan M.
フォーマット: Artigo
言語:Inglês
出版事項: 2004
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889214/
https://ncbi.nlm.nih.gov/pubmed/15542063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2004.09.032
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料