Laddar...

Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85β subunit reveals conformational plasticity in the interhelical turn region

Phosphatidylinositol 3-kinase (PI3K) proteins actively trigger signaling pathways leading to cell growth, proliferation and survival. These proteins have multiple isoforms and consist of a catalytic p110 subunit and a regulatory p85 subunit. The iSH2 domain of the p85β isoform has been implicated in...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Schauder, Curtis, Ma, Li-Chung, Krug, Robert M., Montelione, Gaetano T., Guan, Rongjin
Materialtyp: Artigo
Språk:Inglês
Publicerad: International Union of Crystallography 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998356/
https://ncbi.nlm.nih.gov/pubmed/21139197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110041333
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!