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Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85β subunit reveals conformational plasticity in the interhelical turn region

Phosphatidylinositol 3-kinase (PI3K) proteins actively trigger signaling pathways leading to cell growth, proliferation and survival. These proteins have multiple isoforms and consist of a catalytic p110 subunit and a regulatory p85 subunit. The iSH2 domain of the p85β isoform has been implicated in...

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Autori principali: Schauder, Curtis, Ma, Li-Chung, Krug, Robert M., Montelione, Gaetano T., Guan, Rongjin
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998356/
https://ncbi.nlm.nih.gov/pubmed/21139197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110041333
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