Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110α and are disrupted in oncogenic p85 mutants

We previously proposed a model of Class IA PI3K regulation in which p85 inhibition of p110α requires (i) an inhibitory contact between the p85 nSH2 domain and the p110α helical domain, and (ii) a contact between the p85 nSH2 and iSH2 domains that orients the nSH2 so as to inhibit p110α. We proposed...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wu, Haiyan, Shekar, S. Chandra, Flinn, Rory J., El-Sibai, Mirvat, Jaiswal, Bijay S., Sen, K. Ilker, Janakiraman, Vasantharajan, Seshagiri, Somasekar, Gerfen, Gary J., Girvin, Mark E., Backer, Jonathan M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2009
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787125/
https://ncbi.nlm.nih.gov/pubmed/19915146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902369106
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