Somatic mutations in p85α promote tumorigenesis through class IA PI3K activation

Members of the mammalian phosphoinositide-3-OH kinase (PI3K) family of proteins are critical regulators of various cellular process including cell survival, growth, proliferation and motility. Oncogenic activating mutations in the p110α catalytic subunit of the heterodimeric p110/p85 PI3K enzyme are...

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Detalhes bibliográficos
Main Authors: Jaiswal, Bijay S., Janakiraman, Vasantharajan, Kljavin, Noelyn M., Chaudhuri, Subhra, Stern, Howard M., Wang, Weiru, Kan, Zhengyan, Dbouk, Hashem A., Peters, Brock A., Waring, Paul, Vega, Trisha Dela, Kenski, Denise M., Bowman, Krista, Lorenzo, Maria, Li, Hong, Wu, Jiansheng, Modrusan, Zora, Stinson, Jeremy, Eby, Michael, Yue, Peng, Kaminker, Josh, de Sauvage, Frederic J., Backer, Jonathan M., Seshagiri, Somasekar
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804903/
https://ncbi.nlm.nih.gov/pubmed/19962665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.10.016
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