Demonstration of non-functional beta-globin mRNA in homozygous beta (0) thalassemia.

In two Chinese patients with homozygous beta(0)-thalassemia, messenger RNAs from peripheral blood reticulocytes and the bone marrow failed to direct beta-chain synthesis in vivo and in vitro in a cell-free system. Molecular hybridization showed that the beta cDNA annealed to the RNAs at almost the s...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Kan, Y W, Holland, J P, Dozy, A M, Varmus, H E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1975
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC388892/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1061099/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.72.12.5140
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