Demonstration of non-functional beta-globin mRNA in homozygous beta (0) thalassemia.
In two Chinese patients with homozygous beta(0)-thalassemia, messenger RNAs from peripheral blood reticulocytes and the bone marrow failed to direct beta-chain synthesis in vivo and in vitro in a cell-free system. Molecular hybridization showed that the beta cDNA annealed to the RNAs at almost the s...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1975
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC388892/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1061099/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.72.12.5140 |
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