Demonstration of non-functional beta-globin mRNA in homozygous beta (0) thalassemia.
In two Chinese patients with homozygous beta(0)-thalassemia, messenger RNAs from peripheral blood reticulocytes and the bone marrow failed to direct beta-chain synthesis in vivo and in vitro in a cell-free system. Molecular hybridization showed that the beta cDNA annealed to the RNAs at almost the s...
Saved in:
| Published in: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1975
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC388892/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1061099/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.72.12.5140 |
| Tags: |
No Tags, Be the first to tag this record!
|