Targeted Androgen Pathway Suppression in Localized Prostate Cancer: A Pilot Study

PURPOSE: Ligand-mediated activation of the androgen receptor (AR) is critical for prostate cancer (PCa) survival and proliferation. The failure to completely ablate tissue androgens may limit suppression of PCa growth. We evaluated combinations of CYP17A and 5-α-reductase inhibitors for reducing pro...

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Main Authors: Mostaghel, Elahe A., Nelson, Peter S., Lange, Paul, Lin, Daniel W., Taplin, Mary Ellen, Balk, Steven, Ellis, William, Kantoff, Philip, Marck, Brett, Tamae, Daniel, Matsumoto, Alvin M., True, Lawrence D., Vessella, Robert, Penning, Trevor, Hunter Merrill, Rachel, Gulati, Roman, Montgomery, Bruce
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Clinical Oncology 2014
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ORIGINAL REPORTS
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887479/
https://ncbi.nlm.nih.gov/pubmed/24323034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2012.48.6431
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