Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes

Presenilin-mediated endoproteolysis of transmembrane proteins plays a key role in physiological signaling and in the pathogenesis of Alzheimer disease and some cancers. Numerous inhibitors have been found via library screens, but their structural mechanisms remain unknown. We used several biophysica...

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Main Authors: Li, Yi, Lu, Stephen Hsueh-Jeng, Tsai, Ching-Ju, Bohm, Christopher, Qamar, Seema, Dodd, Roger B., Meadows, William, Jeon, Amy, McLeod, Adam, Chen, Fusheng, Arimon, Muriel, Berezovska, Oksana, Hyman, Bradley T., Tomita, Taisuke, Iwatsubo, Takeshi, Johnson, Christopher M., Farrer, Lindsay A., Schmitt-Ulms, Gerold, Fraser, Paul E., St George-Hyslop, Peter H.
פורמט: Artigo
שפה:Inglês
יצא לאור: Cell Press 2014
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887256/
https://ncbi.nlm.nih.gov/pubmed/24210759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.09.018
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