Interactome Analyses of Mature γ-Secretase Complexes Reveal Distinct Molecular Environments of Presenilin (PS) Paralogs and Preferential Binding of Signal Peptide Peptidase to PS2

γ-Secretase plays a pivotal role in the production of neurotoxic amyloid β-peptides (Aβ) in Alzheimer disease (AD) and consists of a heterotetrameric core complex that includes the aspartyl intramembrane protease presenilin (PS). The human genome codes for two presenilin paralogs. To understand the...

Full description

Saved in:
Bibliographic Details
Main Authors: Jeon, Amy Hye Won, Böhm, Christopher, Chen, Fusheng, Huo, Hairu, Ruan, Xueying, Ren, Carl He, Ho, Keith, Qamar, Seema, Mathews, Paul M., Fraser, Paul E., Mount, Howard T. J., St George-Hyslop, Peter, Schmitt-Ulms, Gerold
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Genomics and Proteomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663554/
https://ncbi.nlm.nih.gov/pubmed/23589300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.441840
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items