Thermodynamic Analysis of the Binding of 2F5 (Fab and Immunoglobulin G Forms) to Its gp41 Epitope Reveals a Strong Influence of the Immunoglobulin Fc Region on Affinity

Immunotherapies and vaccines based on the induction of broadly neutralizing monoclonal antibodies (bNAbs) have become outstanding strategies against HIV-1. Diverse bNAbs recognizing different regions of the HIV-1 envelope have been identified and extensively studied. However, there is little informa...

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Detaylı Bibliyografya
Asıl Yazarlar: Crespillo, Sara, Casares, Salvador, Mateo, Pedro L., Conejero-Lara, Francisco
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2014
Konular:
Reports
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887187/
https://ncbi.nlm.nih.gov/pubmed/24302742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C113.524439
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