The high-affinity immunoglobulin receptor FcγRI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat

The HIV-1 gp41 N-heptad repeat (NHR) region of the prehairpin intermediate, which is transiently exposed during HIV-1 viral membrane fusion, is a validated clinical target in humans and is inhibited by the Food and Drug Administration (FDA)-approved drug enfuvirtide. However, vaccine candidates targ...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Montefiori, David C., Filsinger Interrante, Maria V., Bell, Benjamin N., Rubio, Adonis A., Joyce, Joseph G., Shiver, John W., LaBranche, Celia C., Kim, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826338/
https://ncbi.nlm.nih.gov/pubmed/33431684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2018027118
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