Cancer risks for MLH1 and MSH2 mutation carriers

We studied 17,576 members of 166 MLH1 and 224 MSH2 mutation-carrying families from the Colon Cancer Family Registry. Average cumulative risks of colorectal cancer (CRC), endometrial cancer (EC) and other cancers for carriers were estimated using modified segregation analysis conditioned on ascertain...

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Bibliografische gegevens
Hoofdauteurs: Dowty, James G., Win, Aung K., Buchanan, Daniel D., Lindor, Noralane M., Macrae, Finlay A., Clendenning, Mark, Antill, Yoland C., Thibodeau, Stephen N., Casey, Graham, Gallinger, Steve, Le Marchand, Loic, Newcomb, Polly A., Haile, Robert W., Young, Graeme P., James, Paul A., Giles, Graham G., Gunawardena, Shanaka R., Leggett, Barbara A., Gattas, Michael, Boussioutas, Alex, Ahnen, Dennis J., Baron, John A., Parry, Susan, Goldblatt, Jack, Young, Joanne P., Hopper, John L., Jenkins, Mark A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887142/
https://ncbi.nlm.nih.gov/pubmed/23255516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.22262
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