Cofactor-Independent Phosphoglycerate Mutase from Nematodes Has Limited Druggability, as Revealed by Two High-Throughput Screens

Cofactor-independent phosphoglycerate mutase (iPGAM) is essential for the growth of C. elegans but is absent from humans, suggesting its potential as a drug target in parasitic nematodes such as Brugia malayi, a cause of lymphatic filariasis (LF). iPGAM's active site is small and hydrophilic, i...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Crowther, Gregory J., Booker, Michael L., He, Min, Li, Ting, Raverdy, Sylvine, Novelli, Jacopo F., He, Panqing, Dale, Natalie R. G., Fife, Amy M., Barker, Robert H., Kramer, Martin L., Van Voorhis, Wesley C., Carlow, Clotilde K. S., Wang, Ming-Wei
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886921/
https://ncbi.nlm.nih.gov/pubmed/24416464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002628
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars