Cofactor-Independent Phosphoglycerate Mutase from Nematodes Has Limited Druggability, as Revealed by Two High-Throughput Screens

Cofactor-independent phosphoglycerate mutase (iPGAM) is essential for the growth of C. elegans but is absent from humans, suggesting its potential as a drug target in parasitic nematodes such as Brugia malayi, a cause of lymphatic filariasis (LF). iPGAM's active site is small and hydrophilic, i...

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Detalhes bibliográficos
Main Authors: Crowther, Gregory J., Booker, Michael L., He, Min, Li, Ting, Raverdy, Sylvine, Novelli, Jacopo F., He, Panqing, Dale, Natalie R. G., Fife, Amy M., Barker, Robert H., Kramer, Martin L., Van Voorhis, Wesley C., Carlow, Clotilde K. S., Wang, Ming-Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886921/
https://ncbi.nlm.nih.gov/pubmed/24416464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002628
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