Cofactor-Independent Phosphoglycerate Mutase from Nematodes Has Limited Druggability, as Revealed by Two High-Throughput Screens

Cofactor-independent phosphoglycerate mutase (iPGAM) is essential for the growth of C. elegans but is absent from humans, suggesting its potential as a drug target in parasitic nematodes such as Brugia malayi, a cause of lymphatic filariasis (LF). iPGAM's active site is small and hydrophilic, i...

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Détails bibliographiques
Auteurs principaux: Crowther, Gregory J., Booker, Michael L., He, Min, Li, Ting, Raverdy, Sylvine, Novelli, Jacopo F., He, Panqing, Dale, Natalie R. G., Fife, Amy M., Barker, Robert H., Kramer, Martin L., Van Voorhis, Wesley C., Carlow, Clotilde K. S., Wang, Ming-Wei
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886921/
https://ncbi.nlm.nih.gov/pubmed/24416464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002628
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