Evolution of Bacterial Phosphoglycerate Mutases: Non-Homologous Isofunctional Enzymes Undergoing Gene Losses, Gains and Lateral Transfers

BACKGROUND: The glycolytic phosphoglycerate mutases exist as non-homologous isofunctional enzymes (NISE) having independent evolutionary origins and no similarity in primary sequence, 3D structure, or catalytic mechanism. Cofactor-dependent PGM (dPGM) requires 2,3-bisphosphoglycerate for activity; c...

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Autors principals: Foster, Jeremy M., Davis, Paul J., Raverdy, Sylvine, Sibley, Marion H., Raleigh, Elisabeth A., Kumar, Sanjay, Carlow, Clotilde K. S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964296/
https://ncbi.nlm.nih.gov/pubmed/21187861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013576
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